OCH/OOS Organometallics in Organic Synthesis
Lecturer: Jiří Pospíšil
Lecture: 2 hours/week
Credits: 2
Winter/Summer semester
Form of course completion: colloquium
- Winter term
Lecture No. 1 Introduction to the organometallic chemistry – retrosynthesis. Organometallic compounds of magnesium.
Lecture No.2 and No.3 Group 4: Titanium and Zirconium.
Lecture No.4 and No.5 Group 11 and 12: Copper and Zinc.
Lecture No.6 and No.7 Group 13: Aluminum, Gallium, and Indium.
Lecture No.8 and No.9 Chrome, tin, and silicon.
Lecture No.10 and No.11 Complexes of silver and gold.
Lecture No.12 and No.13 Applications of organometallics in natural product synthesis showcase examples.
- Summer Term
Lecture No.1 and No.2 Introduction to the transition metal-catalyzed organic transformations. Introduction to the reaction mechanisms of transition metal-mediated reactions.
Lecture No.3 and No.4 The role of ligands on the relevant catalytic steps.
Lecture No.5 and No.6 Palladium and Nickel-catalyzed reactions and natural product synthesis.
Lecture No.7 and No.8 Ruthenium mediated metathesis reactions and natural product synthesis.
Lecture No.9 and No.10 Asymmetric catalytic hydrogenation and natural product synthesis.
Lecture No.11 till 13 Asymmetric hydroformylation and iridium promoted C-C bond forming reactions in natural product synthesis.