KFC/STBI Structural Bioinformatics

Lecturer: Karel Berka
Lecture: 1 hour/week + seminar 1 hour/week
Credits: 2
Winter semester
Form of course completion: exam

• Description of biomacromolecules, Structural hierarchy, proteins, nucleic acids
• Structure determination (X-Ray, NMR, EM, etc.)
• Structure file formats
• PDB database
• NDB database
• Other structural databases (CATH, SCOP, Drugbank)
• Vizualization of structure, structural alignment
• Structure prediction, CASP
• Function prediction
• Ligand docking
• Challenges of structural bioinformatics – membrane proteins, nucleic acids, protein-protein interactions prediction