LRR/CHNPA Chemistry of Natural Products
Lecturer: Jiří Pospíšil
Lecture: 2 hours/week
Credits: 5
Summer semester
Form of course completion: exam
- Introduction into biosynthesis
- some definitions – phototrophs, chemotrophs; metabolism (catabolism/anabolism), 1° & 2° metabolites - Origin of metabolism and overview of primary metabolism -> secondary metabolites
- Biological/biosynthetic reactions – enzyme and cofactor chemistry
- The shikimate biosynthetic pathway – phenyl propanoids, lignans and lignins, flavonoids and isoprenoids.
- Fatty acid and polyketide biosynthesis, acetate hypothesis, aliphatic and aromatic compounds
- Terpene and steroid biosynthesis.
- Alkaloid biosynthesis.
- The most important classes of natural organic compounds will be analyzed in terms of chemical structure, biogenesis, stereochemistry, physico-chemical properties, and reactivity. - Carbohydrates: classification and structures of monosaccharides, disaccharides, and glycosides. Protecting Group strategies in the synthesis of glycosides. Chemical transformation of monosaccharides and stereoselective synthesis of glycosides. Nucleosides and nucleotides, glycolipids and glycoproteins.
