KFC/KM Chemistry of Solid Pharmaceutical Substances

Lecturer: Roman Gabriel
Lecture:  2 hours/week
Credits: 2
Winter semester
Form of course completion: colloquium

The lectures include the fundamentals of material chemistry of pharmaceutical substances with particular emphasis on the theory of crystallization, crystallization processes at pharmacy, on physical chemical properties of pharmaceutical substances and analytical procedures used for characterization of solid materials.
 
1. Introduction to the study of solids (classification and properties).
2. Preparation of solids (heterogeneous systems, phase changes, nucleation).
3. Crystalline substances 1 (crystalline state, physical and thermal properties of crystalline substances).  
4. Crystalline substances 2 (solutions and solubility, phase equilibrium).
5. Fundamentals of the crystallization process (nucleation. crystal growth, recrystallization).
6. Crystallization at pharmaceutical industry (batch crystallization, thermodynamic and kinetic crystallization).
7. Polymorphism 1 – property of crystalline solids.
8. Polymorphism 2 – analytical methods for characterization
9. Polymorphism of pharmaceutical compounds (impact on the properties of pharmaceutical substances).
10. The importance of solvates, hydrates and amorphous solids.
11. X-ray powder diffractometry and thermal methods of analysis of powders.
12. Particle Morphology: Optical and Electron microscopies
13. Physical and mechanical property characterization of powders.
14. Summary.