ZOO/IMUN Immunology
Lecturer: Ivana Fellnerová
Lecture: 2 hours/week
Credits: 3
Winter semester
Form of course completion: exam
- Introduction to immunology: historical development of knowledge (Nobel Prize in immunology), basic terminology, IS components (organ, tissue, cellular, molecular), immune mechanisms (innate and adaptive immunity), IS ontogenesis and phylogeny overview.
- Non-specific immunity – components and displays: complement proteins, phagocytosis, TLR receptors; inflammation (classification, signals to development, course, microscopic and macroscopic displays of inflammation).
- Apoptosis: apoptosis vs. necrosis, caspases, basic signalling paths.
- Specific (adaptive) immunity – components and properties: specific receptors, clonal expansion, immunological memory.
- Humoral immunity-B lymphocytes: BCR, immunoglobulin (Ig domain, isotopes), monoclonal and polyclonal antibodies, T lymphocyte-dependent and -independent antibodies.
- Cellular immunity – T lymphocytes: TCR, subpopulation of T lymphocytes (Tc, Th, Th17, Treg, NKT etc.), MHC molecules, HLA system; immunological tolerance.
- Immunogenetics: polymorphisms in IS, genetic basis of BCR or Ig and TCR forming, gene rearrangement, allelic exclusion; construction and heredity of MHC or HLA molecules.
- Bases of transplantation immunology: basic terminology, role of HLA molecules, immunosuppression principals.
- Disorders and diseases of the immune system: allergies, autoimmune diseases, HIV etc.
- Tumours and immune system: how the immune surveillance can miss tumour cells.
- Immunomodulatory therapy, biological therapy.
