CRH/SB Systems Biology

Lecturer: Georgios Komis
Lecture: 2 hours/week
Credits: 4
Winter semester
Form of course completion: exam

• Basic concept, history and tools in systems approaches of biological problems
• Top down and bottom up approaches in modern biology: An introduction.
• Top down: Integration of large scale data into functional networks. Debugging ?omics information
• Bottom up: generation and proof-reading of plausible models
• Chemical biology and chemical genetics
• Synthetic biology: Tailoring life
• Waves and oscillations in cell function. From Belousov?Zhabotinsky reactions to biological non-equilibrium oscillators. Case study I: cell motility and non-equilibrium sol-gel transitions
• Waves and oscillations in cell function. Case study II: the cell cycle as an oscillator
• Waves and oscillations in cell function. Case study III: mitogen activated protein kinase signaling phosphorylation waves, switches and feedback loops
• Waves and oscillations in cell function. Case study IV: circadian systems in plants
• Studying signaling gradients in living cells. Tools, results and interpretation: Ran-GTPase gradients during cell cycle
• Symmetry breaking and symmetry switch as a function of force and morphogen gradient: A systems approach to tissue, organ and organism patterning